The EDUCATE environment provides links to a number of commercial and non-commercial resources relating to flow cytometry and antibody-based techniques. You can link directly to the suppliers' websites.
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Pyroptosis is a form of lytic regulated cell death (RCD) first described by Zychlinsky and colleagues in 1992 as apoptosis, but later renamed as pyroptosis in 2001 by Cookson and Brennan to reflect its inflammatory nature. It is triggered by perturbations of extracellular and intracellular homeostasis in the innate immune system.
Understanding the complexities of stem cell differentiation and development can reveal novel ways to study wound and tissue repair, oncology, neurodegenerative diseases, and more. Explore the pathways of stem cell biology including differentiation from the mesoderm, endoderm, and ectoderm germ layers, iPS cells, and interactions with their niche on our new Stem Cells and Development poster.
Optimized Multicolor Immunofluorescence Panel (OMIP) is a special peer-reviewed Cytometry Part A publication type that reports on newly designed and optimized multicolor panels for flow cytometry, fluorescence microscopy, image cytometry, and other polychromatic fluorescence-based methods. The first two OMIPs were published in the September 2010 issue of the Journal.
Immunology is a complex field with numerous cell types that form a nebulous network of connections. Our new and improved Immunologic Networks poster, developed with guidance from Dr. Vijay Kuchroo at Harvard University, provides a quick overview of both the innate and adaptive branches of the immune system. We've also included sections on topics that are becoming
MIFlowCyt: The minimum information about a flow cytometry experiment
The definition of cell death is the irreversible degeneration of cellular functions resulting in the loss of cellular integrity (Galluzzi et al. 2018). Cell death is a crucial step in organism development, tissue homeostasis, and host defense. There are many mechanisms of regulated cell death (RCD), where signal transduction molecules are not only initiated but also involved in the propagation of cell death.
Immuno-oncology is the interaction between the immune system and cancerous cells (tumors). Immuno-oncology research is not only investigating how the immune system reacts to cancerous cells and how the cancerous cells respond, but also how the immune system can be manipulated to effectively target tumors and eradicate them
Activation and proliferation protocols provide an effective method to determine immunocompetence and cell reactivity. However choosing the right stimulation protocol and knowing when to use it may vary depending on what cell type you are starting with and the result you need.
The major histocompatibility complex (MHC) is comprised of cell membrane proteins that deliver short peptides to the cell surface, presenting these peptide antigens to circulating immune surveillance cells. These peptides are mostly self-peptides however during times of infection these can also be antigens from pathogens that, upon recognition and subsequent binding by the immune cells, specifically T cells, result in the generation of an immune response.