CD4 T helper cells are the primary orchestrators of the adaptive immune response, mediating a variety of cellular and humoral responses against pathogens and cancer. Although they lack any capacity to directly kill or engulf pathogens, they are powerful activators of effector cells such as macrophages, cytotoxic T cells, and B cells.
On the other hand, regulatory T cells (Tregs) are potent suppressors of the immune response important in limiting the immune reaction. Recent advances have led to the discovery of a diverse set of T helper subsets, each with unique functions. Explore them here.