- Beginners Guide (Training Resources)
- Core Facilities, Communities & Societies
- Flow Cytometry Instruments, Software & Upgrades
- Meetings & Conferences
- Online Resources
- Panel Design Resource
- Positions Available
- Reagents, Consumables & Services
- Antibodies in the development of therapeutic products
- Area of Biology
- Blood Controls for Flow Cytometry
- Cell Proliferation
- Cell Separation Techniques
- Clinical Diagnostic Reagents
- Custom / Contract Research Services
- Flow Cytometry & Immunochemical Reagents
- Absolute Cell Counting
- Antibody Panels & Sets
- Antibody Purification
- Cell Health and Proliferation
- EuroFlow™ product line
- Flow Cytometry Buffers
- Flow Cytometry Kits
- Flow Cytometry Validated Antibodies
- Lysis, Fixation & Permeabilisation
- Mitochondrial Staining
- Multimer Reagents
- Sample Stabilization
- Secondary Antibodies
- Viability / DNA Stains
- BioLegend Live Cell / Dead Cell Discrimination
- BioLegend's Viability Dyes
- Bio-Rad Annexin V Apoptosis Kit
- Bio-Rad Apo-BrdU™ TUNEL Apoptosis Assay Kit
- Bio-Rad Caspase FLICA™ Apoptosis Detection Kits
- Bio-Rad Cell Viability Assays
- Bio-Rad MitoPT™ JC-1, TMRE & TMRM Apoptosis Kits
- Bio-Rad PureBlu™ Nuclear Staining Dyes
- Bio-Rad ReadiDrop™ 7-AAD Cell Viability Assay
- Bio-Rad ReadiDrop™ Propidium Iodide Cell Viability Assay
- Bio-Rad VivaFix™ Fixable Viability Dyes
- BioStatus CyTRAK Orange Cell-Permeant DNA probe
- BioStatus DRAQ5 Far-Red Cell-Permeant DNA probe
- BioStatus DRAQ7 DROP & GO
- BioStatus DRAQ7 Far-Red Viability Probe
- Cycloscope™
- ImmunoChemistry Technologies Apoptosie Assays
- Immunostep Apoptosis Tools
- Life Technologies LIVE/DEAD® Cell Viability Assays
- Miltenyi Biotec Annexin V conjugates
- Miltenyi Biotec Viability and DNA stains
- Miltenyi Biotec Viobility™ Fixable Dyes
- SYTOX® Dead Cell Stains (Life Technologies)
- BioStatus DRAQ9
- Flow Cytometry Beads
- Flow Cytometry Consumables
- Fluorescent Dyes & Labelling
- Multiplex Bead Assays
- Set Up & Standardization
- Sourcing Reagents: Help and Advice
- Science News
- Sponsors' Portals
Cycloscope™
Cycloscope™ is an exclusive product line for cell DNA content studies by flow cytometry.
The detection of DNA ploidies and the study of cell cycle phases provide relevant clinical information for prognostic, evaluation and follow-up of patients with solid tumors or hematological malignancies. It has been proved that DNA ploidy is characteristic of malignant neoplasm for some type of diseases. Depending on the type of disease DNA ploidy can be associated with better or worse prognosis. Besides, a high proliferative rate of tumor cells is a condition usually associated to poor clinical outcomes and used for the evaluation of disease progression.
Cycloscope™ main advantage is that it can estimate cell DNA contents on tumor cells combined with their specific immunophenotype identification in a single tube.
Cycloscope™ kits include a specific monoclonal antibody pool to identify neoplasic cells and a ready-to-use DNA labeling solution. Cytognos offers several versions of this reagent:
- Cycloscope™ MM: useful for the evaluation of DNA plasma cell content in Multiple Myeloma (MM) and Monoclonal Gammopathies of Undetermined Significance (MGUS) samples.
- Cycloscope™ B-ALL: suitable for the evaluation of DNA content on neoplasic B-cell precursors in B lineage Acute Lymphoblastic Leukemia (B-ALL) samples.
- Cycloscope™ NHL: designed to determine DNA content on neoplasic B-cells in B-lineage, Non Hodgkin Lymphoma (B-NHL) and other B-cell Chronic Lymphoproliferative Diseases (B-CLPD) samples.
- Cycloscope™ SBC: developed for the screening of DNA content on epithelial cells of bladder cancer urine samples.
- Cycloscope™ Reagent: ready-to-use DNA labeling solution (propidium iodide, permeabilization reagents and RNase) with an erythrocyte lysing solution.
- DNA Labeling Solution: ready-to-use solution that contains propidium iodide, permeabilization reagents and RNase.