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BioLegend MojoSort™ magnetic cell separation system

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MojoSort™ is BioLegend's magnetic cell separation system for the isolation and purification of cells from heterogeneous populations. MojoSort™ offers outstanding performance at an excellent price.

Separation of cells can occur via “Positive Selection” or “Negative Selection” (also known as “Negative Depletion”). This depends on whether the bead-bound antibodies directly target your cells of interest (positive selection) or target unwanted cells (negative selection). Either way, both separated fractions of cells can be used for downstream applications.

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The isolation of a specific cell population from a complex sample has become a common lab procedure. The availability of highly specific antibodies and the demand for targeted applications keeps on pushing the limits of the cell separation field. Thus far, three major techniques have been used for cell separation: centrifugation-based methods, fluorescence-activated cell sorting (FACS), and magnetic cell sorting. FACS and magnetic cell sorting offer the advantage of a more specific isolation, as they use antibodies to select the target population. However, they differ fundamentally in the way they work. So how does magnetic cell separation work?

Basically, specific antibodies that are conjugated to magnetic particles will bind to the cells expressing the target antigen. Applying a magnetic field will attract the cells towards the magnet, separating them from the rest of the cells. Alternatively, a 2-step separation process can be done. For example biotin-antibody conjugates followed by streptavidin-conjugated beads, or a similar approach, can also be used.