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BioLegend's T Regulatory Cells Webpages

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CD4+ T helper cells are the primary orchestrators of the adaptive immune response, mediating a variety of cellular and humoral responses against pathogens and cancer. Although they lack any capacity to directly kill or engulf pathogens, they are powerful activators of effector cells such as macrophages, cytotoxic T cells, and B cells. On the other hand, regulatory T cells (Tregs) are potent suppressors of the immune response important in limiting the immune reaction. Th17 cells are associated with extracellular pathogen defense and inflammatory responses. BioLegend has a variety of T helper webpages to match these subclasses and help you learn more.

T regulatory cells, also known as Tregs, are essential in the maintenance of immune homeostasis and self-tolerance. Naturally occuring Tregs (nTregs) are characterized by the expression of CD4, CD25 and FOXP3, which is a transcription factor important in the development of Tregs. In addition to nTregs, there are several distinct subsets of induced regulatory T cells (iTregs), including Tr1 and Th3. Tregs limit immune activation through a variety of direct and indirect interactions, many of which remain to be defined. Fully understanding Tregs will lead us to harnessing the capacity of these cells in order to develop strategies to limit and prevent autoimmune disorders, tolerance to transplantation, and potentially boosting immune activity against cancer cells.