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Life Technologies' Apoptosis Assays for Flow Cytometry

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Many different approaches are utilized in the study of programmed cell death or apoptosis. Cell death cascades are complex and dynamic, underscoring the importance of a multi-parametric approach to assessment of apoptosis.

Understanding the mechanisms of cell death and survival can represent a critical aspect of toxicological profiling and drug discovery. Invitrogen offers a wide array of apoptosis assays for flow cytometry.

  • Superior Performance—highly sensitive assays to detect early to late events
  • Diverse Selection—Large number of assays to detect different parameters
  • Convenient—ready to use assays with validated flow cytometry protocols
  • Compatible—Many fluorescent options for multiple laser excitation sources

Multiparametric Apoptosis Assays for Flow Cytometry Our multiparametric apoptosis assay kits are designed to selectively differentiate apoptotic cells from living and necrotic cells in a single cell population.

Plasma Membrane

  Annexin V ConjugatesMembrane PermeabilityMembrane Asymmetry
UV
  • Chromatin Condensation/Dead Cell Apoptosis Kit (V13244)
  • Hoechst 33342 (H3570)
--
405
  • Violet Chromatin Condensation/Dead Cell Apoptosis Kit (A35135)
  • Vybrant® DyeCycle™ Violet (V35003)
  • Violet Ratiometric Asymmetry Probe/ Dead Cell Apoptosis Kit (A35137)
488
  • YO-PRO®-1 (Y3603)
  • Membrane Permeability/ Dead Cell Apoptosis Kit (V13243)
 
532 --  
561 -- --
633 --

Mitochondria

  Mitochondrial Membrane PotentialMitochondrial Transition Pore
488
  • MitoProbe™ JC- Assay Kit (M34151)
  • MitoProbe™ DiOC(2)3 Assay Kit (M34150)
  • Mitochondrial Membrane potential/Annexin V Apoptosis Kit with Mitotracker Red (V35116)
  • MitoProbe™ Transition Pore Assay (M34153)
532
  • Dihydrorhodamine 123 (D23806)
 
561
  • TMRE (T669)
  • Mitochondrial Membrane potential/Annexin V Apoptosis Kit with Mitotracker Red (V35116)
--
633
  • MitoProbe™ DiC15 Assay Kit (M34151)
--

Cytoplasm

  Caspase Activity
488
  • Vybrant® FAM Poly Caspases Assay Kit (V35117)
  • Vybrant® FAM Caspase-3 and -7 Assay Kit (V35118)
  • Vybrant Caspase-8 Assay Kit (V35119)

Nucleus

  Chromatin CondensationDNA Fragmentation
UV
  • Chromatin Condensation/Dead Cell Apoptosis Kit (V13244)
  • Hoechst 33342 (H3570)
--
405
  • Vybrant DyeCycle Violet (V35003)
  • Violet Chromatin Condensation/Dead Cell Apoptosis Kit (A35135)
--
488 --
  • APO-BrdU™  TUNEL Assay Kit with Alexa Fluor ® 488 anti-BrdU (A23210)