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pSIVA: Polarity Sensitive Indicator of Viability & Apoptosis
IMGENEX introduces pSIVA, the first reversible apoptosis probe for detecting phosphatidylserine (PS) exposure on plasma membranes. Exclusively available from IMGENEX (2B Scientific Ltd in the UK).
pSIVA and the Kinetics of Apoptosis Applications
• Toxicology Testing
• High-Throughput Screening of Apoptosis Pathways and Processes
• Confocal Microscopy
• Flow Cytometry
• In-vivo Imaging of Apoptosis
pSIVA (Annexin XII) is an Annexin based, polarity sensitive probe for the spatiotemporal or kinetic analysis of apoptosis and other forms of cell death. pSIVA (Annexin XII) binding is reversible enabling researchers, for the first time, to detect transient PS exposure which is associated with normal physiological processes as well as with reversible or rescuable apoptosis cell death events.
pSIVA (Annexin XII) is conjugated to IANBD, a polarity sensitive dye that fluoresces only when pSIVA is bound to the cell membrane. pSIVA’s membrane-bound dependent fluorescence and reversible binding properties are a technological leap for detecting PS exposure and offer additional information on the apoptosis pathway and cell survival compared to Annexin V conjugates. Annexin V binding is nonreversible.
